Science

References to the studies referred to in the handout on Essential Silver™ “Proven! The Fastest Germ Killer”.

 
Silver plays an essential role in our nutrition

 

1.   Jacobson S, Wester PO. Balance study of twenty trace elements during total parenteral nutrition in man. Br. J. Nutr. 1977; 37: 107-126.

https://www.ncbi.nlm.nih.gov/pubmed/402929

2.  Rangwala I, Keating KI. Silver deprivation limits fecundity and survivability in the freshwater crustacean, Daphnia magna. Biol. Trace Elem. Res. 2008; 121(1): 44-50.

https://www.ncbi.nlm.nih.gov/pubmed/18185999

 
Only silver ions are effective in killing infectious organisms

 

3.  Goetz A, Tracy RL, Harris FS Jr. The oligodynamic effect of silver. In: Silver In Industry (L. Addicks, ed.) New York, NY: Reinhold Publishing Corporation; 1940.

4.  Berger TJ, Spadaro JA, Chapin SE, Becker RO. Electrically generated silver ions: quantitative effects on bacterial and mammalian cells. Antimicrob. Agents Chemother. 1976; 9(2): 357-358.

http://aac.asm.org/content/9/2/357.full.pdf

 

5.  Simonetti N, Simonetti G, Bougnol F, Scalzo M. Electrochemical Ag+ for preservative use. Appl. Environ. Microbiol. 1992; 58(12): 3834-3836.

http://aac.asm.org/content/9/2/357.full.pdf

 

6.  Tien DC, Tseng KH, Liao CY, Tsung TT. Identification and quantification of ionic silver from colloidal silver prepared by electric spark discharge system and its antimicrobial potency study. J. Alloys Compounds 2009; 473: 298-302.

https://www.researchgate.net/publication/229107925_Identification_and_quantification_of_ionic_silver_from_colloidal_silver_prepared_by_electric_spark_discharge_system_and_its_antimicrobial_potency_study

 

7.  Morrill K, May K, Leek D, Langland N, Jeane LD, Ventura J, et al. Spectrum of antimicrobial activity associated with ionic colloidal silver. J. Altern. Complement. Med. 2013; 19(3): 224-231.

https://www.researchgate.net/publication/229107925_Identification_and_quantification_of_ionic_silver_from_colloidal_silver_prepared_by_electric_spark_discharge_system_and_its_antimicrobial_potency_study

 

8.  Xiu ZM, Ma J, Alvarez PJJ. Differnetial effect of common ligands and molecular oxygen on antimicrobial activity of silver nanoparticles versus silver ions. Environ. Sci. Technol.  2011; 45: 9003-9008.

https://www.ncbi.nlm.nih.gov/pubmed/23017226

 

9.  Youravong N, Carlen A, Teanpaisan R, Dahlen G. Metal-ion susceptibility of oral bacterial species. Lett. Appl. Microbiol. 2011; 53: 324-328.

https://www.ncbi.nlm.nih.gov/pubmed/21950450

 

Silver preparations that contain mostly silver particles, or silver protein, do not exhibit any antimicrobial activity:

10.  van Hasselt P, Gashe BA, Ahmad J. Colloidal silver as an antimicrobial agent: fact or fiction? J. Wound Care 2004; 12(4): 154-155.

https://www.ncbi.nlm.nih.gov/pubmed/15114827

Silver supports healthy immune function:

 

11.  Edwards-Jones V. The benefits of silver in hygiene, personal care and healthcare. Lett. Appl. Microbiol. 2009; 49: 147-152.

https://www.ncbi.nlm.nih.gov/pubmed/19515146

 

12.  Klippstein R, Fernandez-Montesinos R, Castillo PM, Zaderenko AP, Pozo D. Silver nanoparticles interactions with the immune system: implications for health and disease. In: Silver Nanoparticles (D Pozo, ed.). Rijeka, Croatia: InTech; 2010.

https://www.researchgate.net/publication/221907762_Silver_Nanoparticles_Interactions_with_the_Immune_System_Implications_for_Health_and_Disease

Silver supports healthy immune function by stimulating an increase in production of red and white blood cells

 

13.  Bechold H. Colloids in Biology and Medicine. New York, NY: D. van Nostrand; 1919.

https://archive.org/stream/cu31924104226083/cu31924104226083_djvu.txt

 

14.  Hill WR, Pillsbury D. Argyria: The Pharmacology of Silver. Baltimore, MD: The Williams & Wilkins Company; 1939.

 

15.  Berger TJ, Spadaro JA, Chapin SE, Becker RO. Electrically generated silver ions: quantitative effects on bacterial and mammalian cells. Antimicrob. Agents Chemother. 1976; 9(2): 357-358.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC429529/

 

16.  Becker RO, Spadaro JA. Treatment of orthopedic infections with electrically generated silver ions. J. Bone Joint Surg. Am. 1978; 60(7): 871-881.

https://www.ncbi.nlm.nih.gov/pubmed/701335

Silver supports healthy immune function by increasing the activity of white blood cells

 

17.  Remes A, Williams DF. Neutrophil polarization and immunoelectrophoresis assays in the study of complement activation by biomaterials. Biomat. 1991; 12(6): 607-613.

https://www.ncbi.nlm.nih.gov/pubmed/1772960

 

18.  Xu Y, Tang, H, Liu J, Wang H, Liu Y. Evaluation of the adjuvant effect of silver nanoparticles both in vitro and in vivo. Toxicol. Letters 2013; 219: 42-48.

https://www.ncbi.nlm.nih.gov/pubmed/23454833

19.  Haase H, Fahmi A, Mahltig B. Impact of silver nanoparticles and silver ions on innate immune cells. J. Biomed. Nanotechnol. 2014; 10: 1-11.

https://www.ncbi.nlm.nih.gov/pubmed/24749409

 

 

Silver ions stimulate tissue repair and wound healing

20.  Wright JB, Lam K, Buret AG, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair Regen. 2002; 10:141-151.

https://www.ncbi.nlm.nih.gov/pubmed/12100375

 

21.  Lansdown ABG. Silver in health care: antimicrobial effects and safety in use. Curr. Problems Dermatol. 2006; 33: 17-34. 

https://www.ncbi.nlm.nih.gov/pubmed/16766878

 

 

 

Silver stimulates the process of tissue regeneration from stems cells

22.  Becker RO. Induced dedifferentiation: a possible alternative to embryonic stem cell transplants. NeuroRehab. 2002; 17: 23-31.

https://www.ncbi.nlm.nih.gov/pubmed/12016344

 

23.  Liu X, He W, Fang Z, Kienzle A, Feng Q. Influence of silver nanoparticles on osteogenic differentiation of human mesenchymal stem cells. J. Biomed. Nanotechnol. 2014; 10: 1-9.

https://www.ncbi.nlm.nih.gov/pubmed/24804548

 

24.  Turani M, Banfalvi G, Kukoricza K, Jakim J, Pocsi I, Kemeny-Beke A, et al. Regeneration of limbal stem cells in the presence of silver and gold nanoparticles. J. Environ. Anal. Toxicol. 2015; 5(5): 318.

http://www.omicsonline.org/open-access/regeneration-of-limbal-stem-cells-in-the-presence-of-silver-and-goldnanoparticles-2161-0525-1000318.php?aid=60712

 

25.  Zhang R, Lee P, Lui VC, Chen Y, Liu X, Lok CN, et al. Silver nanoparticles promote osteogenesis of mesenchymal stem cells and improve bone fracture healing in osteogenesis mechanism mouse model. Nanomed. 2015; 11(8):1949-1959.

https://www.ncbi.nlm.nih.gov/pubmed/26282383

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